Implementation and Evaluation of a National Multidisciplinary Kidney Genetics Clinic Network Over 10 Years

K Jayasinghe; E Biros; T Harris; A Wood; R O'Shea; L Hill; L Fowles; L Wardrop; C Shalhoub; D Hahn; G Rangan; L Kevin; M Tchan; P Snelling; R Sandow; M Sundaram; S Chaturvedi; P Trnka; R Faull; NK Poplawski; V Huntley; D Garza; M Wallis; M Jose; A Leaver; AH Trainer; EJ Wilkins; S White; Y Elbaum; Y Prawer; E Krzesinski; G Valente; I Winship; J Ryan; J Whitlam; K Nicholls; K West; L Donaldson; L Johnstone; M Lewit-Mendes; PG Kerr; S Bodek; A Chakera; M MacShane; C Mincham; E Stackpoole; F Willis; J Soraru; N Pachter; B Bennetts; TA Forbes; A Mallawaarachchi; C Quinlan; C Patel; H McCarthy; I Goranitis; S Best; S Alexander; Z Stark; AJ Mallett

Journal article

Implementation and Evaluation of a National Multidisciplinary Kidney Genetics Clinic Network Over 10 Years

K Jayasinghe, E Biros, T Harris, A Wood, R O'Shea, L Hill, L Fowles, L Wardrop, C Shalhoub, D Hahn, G Rangan, L Kevin, M Tchan, P Snelling, R Sandow, M Sundaram, S Chaturvedi, P Trnka, R Faull, NK Poplawski Show all

Kidney International Reports | Published : 2024

DOI: 10.1016/j.ekir.2024.04.068

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Abstract

Introduction: Diagnostic genomic sequencing is the emerging standard of care in nephrology. There is a growing need to scale up the implementation of genomic diagnostics nationally to improve patient outcomes. Methods: This pragmatic study provided genomic or genetic testing to patients with suspected monogenic kidney disease through a national network of kidney genetics clinics (KGCs). We sought to evaluate the experiences of implementing genomic diagnostics across Australia and associated diagnostic outcomes between 2013 and 2022. Results: We successfully established and expanded a nationwide network of 20 clinics as of 2022; concurrently developing laboratory, research, and education prog..

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University of Melbourne Researchers

Alison Trainer Author

Ella Wilkins Author

Susan White Author

Ingrid Winship Author

Related Projects (1)

PREPARING AUSTRALIA FOR GENOMIC MEDICINE: A PROPOSAL BY THE AUSTRALIAN GENOMICS HEALTH ALLIANCE

The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This tec..

Grants

Awarded by State Government of Victoria

Funding Acknowledgements

This work was supported by funding from the Australian Genomics Health Alliance (Australian Genomics), Melbourne Genomics Health Alliance (Melbourne Genomics), Australian Government Department of Health (Activity Reference Number: 4-E8LEZOZ), and Medical Research Future Fund (MRFF; Grant Reference Number: 2008249). Australian Genomics Health Alliance is funded by a National Health and Medical Research Council (NHMRC) grant (Grant Reference Number: 1113531) and the Australian Government's Medical Research Future Fund (MRFF). The research conducted at the Murdoch Children's Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. Clinical activities were supported by all Australian State and Territory Government Departments of Health and Local Hospital and Health Services. AJM was supported by a Queensland Government Advancing Clinical Research Fellowship. This work represents independent research, and the views expressed are those of the authors and not necessarily those of the NHMRC, MRFF, or Australian Government.